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U-47700 is a potent synthetic opioid originally developed in research decades ago and later sold as a designer drug. It is not a fentanyl analog structurally, but it works the same way, strongly activating the mu-opioid receptor to produce pain relief, euphoria, sedation and dangerous respiratory depression. It has been implicated in many overdose deaths, and naloxone reverses its effects.
- Strong pain relief
- Euphoria
- Sedation
- Dangerous respiratory depression
- High overdose risk from potency
- Dependence and withdrawal
Mechanism
U-47700 is a benzamide-derived synthetic opioid that acts as a potent at the mu-opioid receptor, the target underlying opioid analgesia, euphoria, sedation and slowed breathing. It is substantially more potent than morphine, so effects come on at small quantities and overdose is easy. As a mu-opioid drug it is reversible by the naloxone.
receptor fingerprint
Mu-opioid receptorAgonist
Safetyrisks and cautions, not medical advice
U-47700 is potent enough that overdose is easy, and the central danger is respiratory depression, breathing that slows or stops. It has often been sold as a powder or pressed into counterfeit pills, so purity and dose are unpredictable and impossible to judge by eye. It is deadly combined with other depressants such as benzodiazepines and alcohol, and it causes dependence with regular use. Naloxone can reverse an overdose. Not medical advice.
Subjective profileweighing the evidence above
Avoid completely. It is a designer opioid as potent as prescription medicines, sold as loose powder or pressed into counterfeit pills so the dose is unknowable by eye, and it has been implicated in many overdose deaths through respiratory depression. Naloxone reverses it; that is the only reassuring fact here.
Resources
No suppliers are provided for compounds like this. This entry is here for reference.
Research
- 1.U-47700 and Its Analogs: Non-Fentanyl Synthetic Opioids Impacting the Recreational Drug Market.
- 2.Characteristics of fatal 'novel' synthetic opioid toxicity in Australia.
2 listed here; entry last updated August 2026
Reviews
My notesprivate to this device
FAQ
Is U-47700 a fentanyl analog?
No; it has a different chemical structure, but it acts on the same mu-opioid receptor and is similarly potent and dangerous.
Does naloxone reverse it?
Yes. It is a mu-opioid agonist, so the antagonist naloxone can reverse an overdose, though repeat dosing may be needed.
Why has it caused so many deaths?
It is highly potent and was sold as loose powder or fake pills, so people easily took far more than a safe amount.
Adverse effects
- Dangerous respiratory depression
- High overdose risk from potency
- Dependence and withdrawal
Notes and cautions
- Unpredictable purity in the drug supply