data + articles · 2 listed
newest 2012spec sheet10 rows
p-Fluoro-Deprenyl is a para-fluoro analog of selegiline (deprenyl), a selective inhibitor of monoamine oxidase B (MAO-B, an enzyme that breaks down dopamine and related amines in the brain). It is largely a research compound of interest for the catecholaminergic and neuroprotective effects seen with the selegiline family. The fluorine substitution is mainly explored for tuning metabolism and, in labeled form, for brain imaging of MAO-B.
- Selective MAO-B inhibition
- Raised dopaminergic tone
- Antioxidant/neuroprotective interest
- Potential imaging applications when labeled
- MAOI drug and food interactions
- Possible insomnia or overstimulation
- Blood pressure effects if selectivity is lost
Mechanism
Like selegiline, p-fluoro-deprenyl is presumed to act as a selective, irreversible inhibitor of MAO-B, forming a covalent adduct with the enzyme's flavin cofactor so that and other MAO-B substrates are cleared more slowly, raising their availability in the striatum. Selegiline-type molecules also have downstream effects attributed to their metabolites and to reduced oxidative load from amine breakdown, which underlies their neuroprotective reputation. The para-fluoro change is a structural modification presumed to preserve this MAO-B-directed mechanism while altering pharmacokinetics.
receptor fingerprint
MAO-Bselective irreversible inhibitor
Dopaminergic toneindirect enhancer
Safetyrisks and cautions, not medical advice
As an MAO inhibitor, this compound carries the classic MAOI cautions: at higher or non-selective exposure it can interact dangerously with serotonergic drugs (SSRIs, SNRIs, tramadol, MDMA) to cause serotonin syndrome, and loss of MAO-B selectivity raises the risk of hypertensive reactions with tyramine-rich foods and sympathomimetics. It is an obscure research chemical with essentially no human safety data, so any margins should be treated as unknown. Not medical advice.
Subjective profileweighing the evidence above
No reason to pick this over selegiline, which is an actual medicine with actual data. It is an obscure research chemical with essentially no human safety record, and it still carries the full MAOI baggage of food and drug interactions.
Resources
This entry is here for reference.
Research
- 1.In vivo evaluation in cynomolgus monkey brain and metabolism of [¹⁸F]fluorodeprenyl: a new MAO-B pet radioligand.
- 2.(-)deprenyl and (-)parafluorodeprenyl-treatment prevents age-related pigment changes in the substantia nigra. A TV-image analysis of neuromelanin
2 listed here; entry last updated August 2026
Reviews
My notesprivate to this device
FAQ
How is it related to deprenyl?
It is a para-fluoro analog of selegiline (deprenyl), so it is presumed to share selegiline's selective MAO-B inhibiting mechanism.
Does it need MAOI precautions?
Yes; treat it with full MAOI caution, especially avoiding serotonergic drugs and, if selectivity is uncertain, tyramine-rich foods.
Is there human data?
No meaningful human data exists; it is a research compound, so any dosing or safety margins are unknown.
Limitations of the evidence
- Unstudied long-term profile
Adverse effects
- MAOI drug and food interactions
- Possible insomnia or overstimulation
- Blood pressure effects if selectivity is lost