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Corallocin B is a benzofuranone natural product isolated from the mushroom Hericium coralloides alongside corallocins A and C. It induces nerve growth factor and brain-derived neurotrophic factor expression in human astrocytes and, unusually for this class, also shows antiproliferative activity against endothelial and cancer cell lines. This combination of neurotrophic and antiproliferative properties makes it a distinctive dual-activity member of the Hericium neuroactive metabolites.
- Induces both NGF and BDNF in astrocytes
- Supports neurotrophic signaling for neuronal survival
- Shows antiproliferative activity against cancer cell lines
- Distinctive dual neurotrophic and cytostatic profile
- Expands the known bioactivity of Hericium mushrooms
Overview
Corallocin B is one of three new natural products, corallocins A through C, isolated from the mushroom Hericium coralloides and structurally characterized as benzofuranone and isoindolinone metabolites. Like its siblings, corallocin B induced nerve growth factor and brain-derived neurotrophic factor expression in human 1321N1 astrocytes, placing it among the dual-neurotrophin inducers of the genus [1].
What distinguishes corallocin B is an additional antiproliferative activity. In the same study it showed growth inhibition against human umbilical vein endothelial cells (HUVEC) and the human cancer cell lines MCF-7 breast carcinoma and KB-3-1, an activity not shared by corallocin A [1]. This gives corallocin B a dual pharmacological character, combining neurotrophic induction with cytostatic effects, and marks it as a more complex lead than the purely neurotrophic Hericium compounds [2][3].
The neurotrophic side connects corallocin B to the broader Hericium theme of raising NGF and BDNF to support neuronal survival, neurite outgrowth and synaptic plasticity, while the antiproliferative side invites interest in antivascular and antitumor contexts. All evidence is preclinical and cell-based, and the compound is a research isolate rather than a consumer ingredient. Its dual profile means any future development would need to weigh neurotrophic benefit against antiproliferative effects on normal cells.
- Corallocin B does two things at once: it induces nerve-growth neurotrophins and slows the growth of certain endothelial and cancer cells.
- It is a benzofuranone, a different structure from its sibling corallocin A, which is an isoindolinone.
- Its antiproliferative activity was seen against breast carcinoma and other cancer cell lines in the lab.
Mechanism
Corallocin B is a benzofuranone that induces nerve growth factor and brain-derived neurotrophic factor expression in astrocytes, supporting TrkA and neurotrophic signaling to . Independently it exerts antiproliferative activity against endothelial and cancer cell lines, indicating a cytostatic action whose molecular basis is not fully defined but that separates it from the purely neurotrophic corallocin A.
receptor fingerprint
and expressionInduces in human astrocytes
Endothelial cell proliferation (HUVEC)Inhibits growth
Cancer cell lines (MCF-7, KB-3-1)Antiproliferative
Dosingtypical ranges, not medical advice
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Safetyrisks and cautions, not medical advice
Corallocin B is a minor constituent of Hericium mushrooms and exists mainly as a research isolate, with no dedicated human safety data. Its antiproliferative activity against normal endothelial cells is a theoretical caution that further separates it from food-grade neurotrophic use, and it is not characterized for any human application, including pregnancy and lactation.
History
Corallocin B was described in 2016 by the Helmholtz Centre for Infection Research group that isolated the corallocins from Hericium coralloides, elucidating the benzofuranone and isoindolinone structures by spectroscopic methods and reporting both neurotrophic and, for corallocin B, antiproliferative activity.
Reputation
Corallocin B is a specialist research compound known for its unusual pairing of neurotrophin induction and antiproliferative activity. It has essentially no consumer profile and is discussed mainly in natural-product chemistry as an example of the diverse bioactivity within Hericium mushrooms.
Subjective profileweighing the evidence above
Not a product and not a supplement; it is a trace mushroom isolate studied in cell models. The dual NGF and BDNF induction is interesting, and its antiproliferative activity against normal endothelial cells is exactly why it should not be treated as a food-grade Lion's Mane substitute.
Resources
This entry is here for reference.
Research
- 2016first citedCorallocins A-C, Nerve Growth and Brain-Derived Neurotrophic Factor Inducing Metabolites from t…
- 2026most recentBeyond Neurotrophins: A Proposed Neurotrophic-Epigenetic Axis Mediated by Non-Coding RNA Networ…
- 1.Corallocins A-C, Nerve Growth and Brain-Derived Neurotrophic Factor Inducing Metabolites from the Mushroom Hericium coralloides
- 2.Neurotrophic and Neuroprotective Effects of Hericium erinaceus
- 3.Beyond Neurotrophins: A Proposed Neurotrophic-Epigenetic Axis Mediated by Non-Coding RNA Networks for Hericium erinaceus Bioactives-A Hypothesis-Driven Review.
3 listed here; entry last updated August 2026
Reviews
My notesprivate to this device
FAQ
How is corallocin B different from corallocin A?
Both induce NGF and BDNF, but corallocin B additionally inhibits proliferation of endothelial and cancer cells, an antiproliferative activity corallocin A lacks, and it is a benzofuranone rather than an isoindolinone.
Is corallocin B a supplement?
No. It is a research isolate and a trace constituent of Hericium mushrooms, not a consumer product.
Why is the antiproliferative activity notable?
It suggests potential antivascular or antitumor uses, but it also means the compound affects normal cell growth, which complicates any nutritional use.
Does it help memory?
It induces BDNF and NGF in cell models, which is memory-relevant in principle, but there is no cognitive or human data for the isolated compound.
What pairs conceptually with it?
As a research compound it is not stacked in practice; within the genus its neurotrophic side aligns with whole Lion's Mane extract.
Limitations of the evidence
- No human safety or efficacy data
- Uncharacterized in any clinical context
Notes and cautions
- Antiproliferative activity against normal endothelial cells
- Research-grade only with no established dosing