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for educational and safety purposes
YK-11 and LGD-4033 both come up in the same conversations; they overlap on Muscle Growth. YK-11: YK-11 is a synthetic steroidal SARM (selective androgen receptor modulator) famous in bodybuilding circles as a myostatin inhibitor, prized for its potential to push muscle growth past the body's natural limits. LGD-4033: LGD-4033, also known as ligandrol or VK5211, is an investigational nonsteroidal selective androgen receptor modulator, a class of compounds abbreviated as SARM.
YK-11 is a synthetic steroidal SARM (selective androgen receptor modulator) famous in bodybuilding circles as a myostatin inhibitor, prized for its potential to push muscle growth past the body's natural limits. Uniquely among SARMs, it drives muscle cells to produce follistatin, a protein that blocks myostatin, the built-in brake on muscle size. This dual action as both an androgen receptor activator and a follistatin booster has made YK-11 one of the most talked-about compounds for lean mass, though it remains an experimental, unapproved research chemical.
LGD-4033, also known as ligandrol or VK5211, is an investigational nonsteroidal selective androgen receptor modulator, a class of compounds abbreviated as SARM. It binds the androgen receptor, the same target acted on by testosterone, but is designed to stimulate muscle and bone while having weaker effects on other tissues. First described by Ligand Pharmaceuticals and later developed by Viking Therapeutics, it has been studied for muscle wasting but is not approved for any medical use, and it is banned in sport and sold illicitly to bodybuilders.
both fingerprints on one instrument; where the marks line up the two compounds work the same lever, where a slot goes dark only one of them touches it. read straight from each entry's affinity table; nothing here is invented.
partial agonist
Selective tissue-preferential agonist
inhibits (via follistatin)
raises
Dose-dependent suppression of endogenous testosterone
Lowers HDL and SHBG dose-dependently
strengths are the entries' qualitative ratings (strong / moderate / weak); Ki and EC50 figures appear where an entry records them.
easiest to source: YK-11 is currently listed by more trusted vendors (2), so it's the simpler one to get hold of. for effects and safety, read each full entry; this is educational, not medical advice.