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for educational and safety purposes
Psilocybin and Psilocybin mushrooms both come up in the same conversations; they overlap on Serotonin. Psilocybin: Psilocybin (4-phosphoryloxy-N,N-dimethyltryptamine) is the principal psychoactive alkaloid of the Psilocybe genus of mushrooms and one of the most clinically researched classic psychedelics. Psilocybin mushrooms: Psilocybin mushrooms are fungi, chiefly of the genus Psilocybe, that contain psilocybin, a phosphorylated tryptamine that the body dephosphorylates into the active metabolite psilocin.
Psilocybin (4-phosphoryloxy-N,N-dimethyltryptamine) is the principal psychoactive alkaloid of the Psilocybe genus of mushrooms and one of the most clinically researched classic psychedelics. It is itself essentially inactive and functions as a prodrug: after ingestion it is rapidly dephosphorylated by alkaline phosphatase to psilocin, the tryptamine that actually crosses into the brain and drives the experience through agonism at serotonin 5-HT2A receptors. In controlled clinical trials, psilocybin combined with psychological support has shown rapid and sometimes durable antidepressant effects, including a head-to-head study against the antidepressant escitalopram, alongside signals in anxiety, substance use disorders, and end-of-life distress. Neuroimaging suggests its antidepressant action may involve a transient global increase in brain network integration that outlasts the acute drug effect. It is generally physiologically well tolerated, with nausea and headache the most common adverse effects.
Psilocybin mushrooms are fungi, chiefly of the genus Psilocybe, that contain psilocybin, a phosphorylated tryptamine that the body dephosphorylates into the active metabolite psilocin. Psilocin acts primarily as an agonist at the 5-HT2A serotonin receptor; crystallographic and structure-activity studies show that the 4-position hydroxyl of the indole ring anchors the molecule in the receptor's orthosteric pocket and drives efficacious signaling, producing a several-hour psychedelic experience. Neuroimaging links the acute state to reorganization of large-scale brain network integration and segregation that tracks plasma psilocin levels, and controlled clinical trials have reported rapid antidepressant effects, including in treatment-resistant depression and in head-to-head comparison with escitalopram. The mushrooms carry low physiological toxicity but produce powerful psychological effects and pose a real risk of misidentification with poisonous species.
both fingerprints on one instrument; where the marks line up the two compounds work the same lever, where a slot goes dark only one of them touches it. read straight from each entry's affinity table; nothing here is invented.
agonist (via psilocin)
agonist (via psilocin)
agonist (via psilocin)
agonist
agonist (via psilocin)
agonist
substrate (dephosphorylation to psilocin)
strengths are the entries' qualitative ratings (strong / moderate / weak); Ki and EC50 figures appear where an entry records them.