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for educational and safety purposes
Fentanyl and Heroin both come up in the same conversations; they overlap on Mu-opioid receptor and Pain. Fentanyl: Fentanyl is a powerful synthetic opioid used medically for anesthesia and for severe pain, including breakthrough cancer pain. Heroin: Heroin (diacetylmorphine, or diamorphine in medicine) is a fast-acting semisynthetic opioid made by acetylating morphine.
Fentanyl is a powerful synthetic opioid used medically for anesthesia and for severe pain, including breakthrough cancer pain. It acts on mu-opioid receptors in the nervous system and is estimated to be roughly 50 to 100 times more potent than morphine. In recent years, illicitly manufactured fentanyl has become a leading cause of drug overdose deaths.
Heroin (diacetylmorphine, or diamorphine in medicine) is a fast-acting semisynthetic opioid made by acetylating morphine. It is a prodrug; the body strips the acetyl groups off to release 6-monoacetylmorphine and morphine, which switch on mu-opioid receptors to produce pain relief, a rush of euphoria, and dangerous slowing of breathing.
both fingerprints on one instrument; where the marks line up the two compounds work the same lever, where a slot goes dark only one of them touches it. read straight from each entry's affinity table; nothing here is invented.
agonist
agonist (via 6-MAM and morphine)
agonist
agonist
agonist
agonist
modulates
agonist
crosses rapidly
deacetylated by
binds directly
strengths are the entries' qualitative ratings (strong / moderate / weak); Ki and EC50 figures appear where an entry records them.