for educational and safety purposes

DOI vs DOM

DOI and DOM both come up in the same conversations; they overlap on Serotonin. DOI: DOI (2,5-dimethoxy-4-iodoamphetamine) is a potent, long-acting psychedelic amphetamine of the DOx family bearing an iodine substituent at the 4 position of the ring. DOM: DOM (2,5-dimethoxy-4-methylamphetamine), historically distributed as STP, is a potent, long-acting psychedelic amphetamine of the DOx family carrying a methyl group at the 4 position.

DOI

PhenethylamineSerotonergicSerious Drug

DOI (2,5-dimethoxy-4-iodoamphetamine) is a potent, long-acting psychedelic amphetamine of the DOx family bearing an iodine substituent at the 4 position of the ring. It acts as a high-affinity agonist at serotonin 5-HT2A receptors, and its radioiodinated form ([125I]DOI) became the standard agonist radioligand for mapping and quantifying 5-HT2A and 5-HT2C receptor populations in brain and peripheral tissue. Because its hallucinogenic potency correlates closely with 5-HT2A affinity, DOI is widely used as a reference tool compound in drug discrimination and head-twitch assays that define the class. Beyond its psychoactive effects, the (R)-enantiomer has attracted interest for potent anti-inflammatory activity mediated through peripheral 5-HT2A receptors, alongside more recent findings of 5-HT2A-dependent anxiolytic and antinociceptive effects in rodent models. In humans it produces a prolonged psychedelic state with a stimulant character and the vasoconstriction typical of the DOx series.

effects: Serotonin
targets: 5-HT2A receptor, 5-HT2C receptor
suppliers: reference only

Full DOI entry →

DOM

PhenethylamineSerotonergicSerious Drug

DOM (2,5-dimethoxy-4-methylamphetamine), historically distributed as STP, is a potent, long-acting psychedelic amphetamine of the DOx family carrying a methyl group at the 4 position. It acts chiefly as an agonist at serotonin 5-HT2A receptors, and its potency correlates with 5-HT2 binding affinity, a relationship established in the radioligand studies that helped implicate this receptor as the common site of action for phenylisopropylamine hallucinogens. Synthesized by Alexander Shulgin and later characterized extensively in rodent and primate drug-discrimination work, DOM became a widely used training drug for probing 5-HT2A-mediated interoceptive effects and for screening novel agonists and antagonists. It gained notoriety after high-dose tablets were distributed on the street in 1967, producing prolonged, difficult experiences and a wave of hospital presentations. The compound produces a long psychedelic state with a stimulant edge and pronounced body load.

effects: Serotonin
targets: 5-HT2A receptor, 5-HT2C receptor
suppliers: reference only

Full DOM entry →

receptor bench

both fingerprints on one instrument; where the marks line up the two compounds work the same lever, where a slot goes dark only one of them touches it. read straight from each entry's affinity table; nothing here is invented.

reading the marksactivatesblocks / inhibitsmodulates