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for educational and safety purposes
2C-B-FLY and Bromo-DragonFLY both come up in the same conversations; they overlap on Serotonin. 2C-B-FLY: 2C-B-FLY is the tetrahydrobenzodifuran ("FLY") analog of 2C-B, in which the 2- and 5-methoxy groups are locked into fused dihydrofuran rings, conformationally constraining the molecule into an orientation favorable for serotonin 5-HT2A receptor binding. Bromo-DragonFLY: Bromo-DragonFLY is a benzodifuran psychedelic, a conformationally rigid analog of DOB in which the phenethylamine is locked into a winged 'dragonfly' shape that greatly enhances affinity and residence at the 5-HT2A receptor.
2C-B-FLY is the tetrahydrobenzodifuran ("FLY") analog of 2C-B, in which the 2- and 5-methoxy groups are locked into fused dihydrofuran rings, conformationally constraining the molecule into an orientation favorable for serotonin 5-HT2A receptor binding. It acts principally as a 5-HT2A receptor agonist, and in vitro profiling shows potent interaction with 5-HT2 receptors together with a predicted risk of vasoconstriction; in mouse head-twitch assays it is roughly equipotent with 2C-B, whereas full aromatization to the benzodifuran ("DragonFLY") markedly increases potency. Metabolism proceeds mainly through CYP2D6-mediated hydroxylation and N-acetylation, with additional monoamine oxidase involvement noted for related FLY compounds. The substance has been linked to serious and fatal intoxications, in part because of confusion with, or contamination by, the far more potent and long-acting Bromo-DragonFLY, whose resistance to hepatic metabolism and prolonged vasoconstrictor action have produced documented deaths. It is detectable in urine alongside other 2C designer drugs by liquid chromatography-mass spectrometry methods.
Bromo-DragonFLY is a benzodifuran psychedelic, a conformationally rigid analog of DOB in which the phenethylamine is locked into a winged 'dragonfly' shape that greatly enhances affinity and residence at the 5-HT2A receptor. It is an extraordinarily potent and unusually long-acting 5-HT2A agonist and displays biased, functionally selective signaling at the receptor; it is also resistant to hepatic metabolism and potently inhibits monoamine oxidase A, properties that help explain its very long duration. Pronounced serotonergic and adrenergic vasoconstriction has produced severe limb and peripheral ischemia, and delayed-onset seizures, mass-poisoning incidents, and fatalities have been documented. It is regarded as one of the more hazardous psychedelics known.
both fingerprints on one instrument; where the marks line up the two compounds work the same lever, where a slot goes dark only one of them touches it. read straight from each entry's affinity table; nothing here is invented.
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strengths are the entries' qualitative ratings (strong / moderate / weak); Ki and EC50 figures appear where an entry records them.