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for educational and safety purposes
25I-NBOMe and 25C-NBOMe both come up in the same conversations; they overlap on Serotonin. 25I-NBOMe: 25I-NBOMe is the N-(2-methoxybenzyl) derivative of 2C-I and the best-known member of the NBOMe family, sometimes sold on blotter paper as "N-bomb." The 2-methoxybenzyl substitution raises 5-HT2A receptor affinity into the sub-nanomolar range and yields a highly potent full agonist, a property exploited in neuroscience through its radiolabeled analogue 11C-CIMBI-5, used as a 5-HT2A agonist radioligand for positron-emission-tomography imaging of the receptor's active state. 25C-NBOMe: 25C-NBOMe is the N-(2-methoxybenzyl) derivative of 2C-C and one of the most frequently encountered members of the NBOMe family.
25I-NBOMe is the N-(2-methoxybenzyl) derivative of 2C-I and the best-known member of the NBOMe family, sometimes sold on blotter paper as "N-bomb." The 2-methoxybenzyl substitution raises 5-HT2A receptor affinity into the sub-nanomolar range and yields a highly potent full agonist, a property exploited in neuroscience through its radiolabeled analogue 11C-CIMBI-5, used as a 5-HT2A agonist radioligand for positron-emission-tomography imaging of the receptor's active state. Pharmacological studies attribute its hallucinogenic activity and its effects on cortical dopamine, serotonin, and glutamate release chiefly to 5-HT2A with a contribution from 5-HT2C, and it is metabolized largely by CYP3A4. The compound is essentially inactive orally and is taken sublingually; a large clinical and forensic literature documents numerous poisonings and deaths, frequently after it was mis-sold as LSD, as well as persistent sequelae such as hallucinogen-persisting perception disorder.
25C-NBOMe is the N-(2-methoxybenzyl) derivative of 2C-C and one of the most frequently encountered members of the NBOMe family. The 2-methoxybenzyl substitution confers high, near-subnanomolar affinity and full agonist activity at the 5-HT2A receptor, so the compound is active at microgram doses and is distributed on blotter paper, often after being mis-sold as LSD. It is subject to extensive first-pass metabolism and is used sublingually rather than orally. A substantial forensic and clinical literature documents severe and fatal intoxications, in which vasoconstriction, seizures, hyperthermia, metabolic acidosis, rhabdomyolysis, and multi-organ failure are recurrent features.
both fingerprints on one instrument; where the marks line up the two compounds work the same lever, where a slot goes dark only one of them touches it. read straight from each entry's affinity table; nothing here is invented.
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strengths are the entries' qualitative ratings (strong / moderate / weak); Ki and EC50 figures appear where an entry records them.