vasculature

Every compound in the sci-wiki that affects vasculature; the ones you can source are floated to the front, then the reference-only entries. Tap any for the full entry, mechanism, and outlets.

4 sourced · 0 reference

←vasculature4/4

PDE5

Avanafil

Avanafil is a phosphodiesterase type 5 (PDE5) inhibitor used to treat erectile dysfunction, sold under the brand names Stendra and Spedra. It is notable for its fast onset, being absorbed within roughly thirty to forty-five minutes, and for its high selectivity for the PDE5 enzyme. Invented at Mitsubishi Tanabe Pharma and approved by the US Food and Drug Administration in 2012, it works by boosting the nitric-oxide signaling that relaxes blood vessels in the penis.

1 outlet

ARB

Candesartan

Candesartan is an angiotensin II receptor blocker (ARB), a class of drugs that lower blood pressure by blocking the effects of the hormone angiotensin II. Marketed mainly as Atacand and taken by mouth as the prodrug candesartan cilexetil, it is used to treat high blood pressure and chronic heart failure. It has also been studied for preventing migraine and, like other ARBs, is generally well tolerated.

1 outlet

Beta-Blocker

Carvedilol

Carvedilol is a medication of the beta-blocker class that also blocks alpha-1 adrenergic receptors, sometimes described as a third-generation beta-blocker. Sold under brand names such as Coreg, it is used chiefly to treat chronic heart failure, high blood pressure, and left ventricular dysfunction after a heart attack. By blunting the effects of adrenaline on the heart and relaxing blood vessels, and through additional antioxidant properties, it improves survival in heart failure and is considered a standard therapy.

1 outlet

Cardiovascular

Cilnidipine

Cilnidipine is a dihydropyridine calcium channel blocker used to treat high blood pressure. Unlike most drugs in its class, it blocks both L-type and N-type calcium channels, the latter located on sympathetic nerve endings, which lets it lower blood pressure while limiting the reflex rise in heart rate seen with some other calcium antagonists. It was approved for medical use in the mid-1990s and is marketed mainly in Japan and several other Asian countries.

1 outlet