Serotonin system

Every compound in the sci-wiki that affects serotonin system; the ones you can source are floated to the front, then the reference-only entries. Tap any for the full entry, mechanism, and outlets.

1 sourced · 3 reference

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Antidepressant

Tianeptine

Tianeptine is an atypical antidepressant, chemically related to the tricyclic antidepressants, that has been used since the 1980s to treat major depressive disorder and anxiety, mainly in parts of Europe, Asia, and Latin America under brand names such as Stablon and Coaxil. Long thought to work by an unusual effect on serotonin, it was later shown to be an agonist at the mu-opioid receptor, with weaker action at the delta-opioid receptor, which is now regarded as central to its effects [1][2]. This opioid activity also underlies a growing problem of misuse; sold in some markets as an unapproved supplement and nicknamed gas station heroin, tianeptine can cause opioid-like euphoria, dependence, and withdrawal, and it is not approved as a medicine in the United States [1].

2 outlets

reference shelf; no outlet carries these yet

Nootropic

AVN-322

AVN-322 is an investigational, highly selective 5-HT6 serotonin receptor antagonist developed by Avineuro Pharmaceuticals as a potential cognitive-enhancing treatment for Alzheimer's disease.

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Serotonergic

AZD-1134

AZD-1134 is an investigational, selective serotonin 5-HT1B receptor antagonist that AstraZeneca researched preclinically as a potential treatment for major depressive and anxiety disorders.

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Serotonergic

AZD-3783

AZD-3783 is an investigational, selective serotonin 5-HT1B receptor antagonist that AstraZeneca developed as a potential treatment for major depressive and anxiety disorders.

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