Senescence

Every compound in the sci-wiki that affects senescence; the ones you can source are floated to the front, then the reference-only entries. Tap any for the full entry, mechanism, and outlets.

1 sourced · 1 reference

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Peptide

FOX-04-DRI

FOX-04-DRI is one of the most elegantly targeted ideas in longevity science, a peptide senolytic engineered to seek out and clear senescent "zombie" cells while sparing healthy ones. It works by breaking the FOXO4-p53 grip that keeps worn-out cells alive and inflammatory, freeing them to self-destruct. In aged animals this has produced genuine signs of rejuvenation, from restored vitality to recovered testosterone, making FOX-04-DRI a captivating frontier tool for anyone following the biology of aging.

5 outlets

reference shelf; no outlet carries these yet

Immunomodulator

Dapansutrile

Dapansutrile (OLT1177) is an orally active beta-sulfonyl nitrile small molecule that selectively inhibits the NLRP3 inflammasome, blocking maturation and release of the pro-inflammatory cytokines interleukin-1 beta and interleukin-18. Developed by Olatec Therapeutics, it is investigational and has completed early-phase human trials in gout and systolic heart failure with a favorable safety profile.

reference