Satellite cells

Every compound in the sci-wiki that affects satellite cells; the ones you can source are floated to the front, then the reference-only entries. Tap any for the full entry, mechanism, and outlets.

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Peptide

IGF-1 DES

IGF-1 DES, formally des(1-3)IGF-I, is a naturally occurring truncated form of insulin-like growth factor 1 that is roughly 10-fold more potent than standard IGF-1 at stimulating cell growth and proliferation [1][4]. The single change, removal of the first three amino acids from the N-terminus, sharply lowers its affinity for the IGF-binding proteins that normally restrain IGF-1, so more of the peptide reaches its receptor in active form [1][4]. This makes IGF-1 DES a potent anabolic research peptide with a distinctive, well-documented mechanism for escaping the body's own IGF buffering system [1][4].

2 outlets

Peptide

MGF

MGF, or Mechano Growth Factor, is a muscle-derived splice variant of IGF-1 that the body releases in response to mechanical loading and tissue damage. Prized in muscle biology for its role in activating satellite cells and driving local repair, its distinctive C-terminal peptide has become a focal point of regenerative and performance research. It remains one of the most scientifically interesting, and most actively debated, peptides in the growth factor field.

1 outlet

Peptide

PEG-MGF

PEG-MGF is a stability-engineered form of mechano growth factor (MGF), a splice variant of the IGF-1 gene that is switched on in muscle by mechanical loading and damage. Its C-terminal peptide is proposed to act as an early trigger that activates satellite (muscle stem) cells for repair before systemic IGF-1 takes over, and attaching a polyethylene glycol group is intended to extend its very short circulating life. Whether the synthetic C-terminal MGF peptide has genuine biological activity is still scientifically disputed, with published studies on both sides, and PEG-MGF remains an unapproved research peptide.

2 outlets