PPAR-alpha

Every compound in the sci-wiki that affects ppar-alpha; the ones you can source are floated to the front, then the reference-only entries. Tap any for the full entry, mechanism, and outlets.

1 sourced · 1 reference

←ppar-alpha2/2

Cardiovascular

Fenofibrate

Fenofibrate is a lipid-lowering medication of the fibrate class, used mainly to reduce high triglyceride levels and to manage mixed dyslipidemia. It is a prodrug that the body converts to its active form, fenofibric acid, which switches on a receptor called PPAR-alpha to change how the body handles fats. Sold under brand names such as Tricor, it is taken by mouth and is often combined with a statin.

1 outlet

reference shelf; no outlet carries these yet

Cannabinoid

PF-3845

PF-3845 is a highly selective, covalent fatty acid amide hydrolase (FAAH) inhibitor developed by Pfizer as a pharmacological tool to augment endocannabinoid signaling in vivo. By carbamylating the serine nucleophile of FAAH, the enzyme responsible for degrading the endocannabinoid anandamide, PF-3845 raises brain and peripheral levels of anandamide and related N-acylethanolamines for up to 24 hours after a single dose. It is widely used in preclinical neuroscience to probe endocannabinoid contributions to pain, inflammation, anxiety, and nausea, and remains an investigational research compound rather than an approved drug.

reference