norepinephrine reuptake

Every compound in the sci-wiki that affects norepinephrine reuptake; the ones you can source are floated to the front, then the reference-only entries. Tap any for the full entry, mechanism, and outlets.

1 sourced · 1 reference

←norepinephrine reuptake2/2

Antidepressant

Venlafaxine

Venlafaxine is a serotonin-norepinephrine reuptake inhibitor (SNRI) used for major depressive disorder and several anxiety disorders, and available in immediate-release and extended-release forms. It is distinguished by an ascending dose-response relationship: at low doses it behaves much like a selective serotonin reuptake inhibitor, while progressively higher doses recruit norepinephrine reuptake inhibition, which contributes both to added efficacy and to dose-dependent increases in blood pressure. Beyond monoamine transport, preclinical work implicates sigma-1 receptor modulation in its antidepressant action, and the drug is widely repurposed as an effective nonhormonal treatment for menopausal and cancer-therapy-related hot flashes. Network meta-analyses place it among the more efficacious antidepressants, although tolerability, cardiovascular effects in overdose, and a pronounced discontinuation syndrome temper its use.

2 outlets

reference shelf; no outlet carries these yet

Modulators

Astra2959

Astra2959 is an obscure research chemical identified by vendors as N,N-dimethyl-3,3-diphenylcyclobutanamine hydrochloride, the N,N-dimethyl analog of 3,3-diphenylcyclobutanamine. The parent scaffold is a psychostimulant originally explored as an antidepressant in the late 1970s that inhibits reuptake of serotonin, norepinephrine and dopamine; the N,N-dimethyl form is reported to be the most potent locomotor stimulant of the series. Rigorous, compound-specific published data on Astra2959 itself are essentially absent.

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