Nitric Oxide: nootropics and compounds | sci-wiki

Acetildenafil

Acetildenafil, also known as hongdenafil, is a designer analogue of sildenafil (Viagra) and one of the prototype sildenafil-like PDE5 inhibitors that surfaced in all-natural male-enhancement supplements. Built to mimic sildenafil's blood-flow-boosting mechanism, it delivers erectile-support effects without the branding of a prescription drug, which made it one of the earliest and most widely copied research analogues in the space. It is sought out in gray-market circles precisely for reproducing a pharmaceutical effect in an unregulated form.

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Blend

Herc (mtb)

HERC (MTB) is a compounded amino acid blend engineered around the two levers endurance athletes care about most: blood flow and cellular energy. It pairs L-arginine and L-citrulline, which raise nitric oxide to widen vessels and improve muscle oxygenation, with L-carnitine, the carrier that ferries fatty acids into mitochondria for fuel, and L-glutamine for recovery and ammonia handling [1][2][6]. Each component rests on its own peer-reviewed evidence base, giving the blend a mechanistically grounded rationale [1][5][6]. It is supplied for laboratory research.

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Cardiovascular

Riociguat

Riociguat is an oral medication in a class of drugs called soluble guanylate cyclase stimulators, and it was the first agent of this type to reach the market. It is used to treat two forms of pulmonary hypertension: chronic thromboembolic pulmonary hypertension that persists after or cannot be corrected by surgery, and pulmonary arterial hypertension. Developed by Bayer, it is sold under the brand name Adempas.

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Blend

Sildenafil + Tadalafil

Sildenafil plus tadalafil is the combined use of two phosphodiesterase type 5 (PDE5) inhibitors for erectile dysfunction, typically a longer-acting daily tadalafil together with on-demand sildenafil. The strategy is generally reserved for men who respond poorly to a single PDE5 inhibitor. Because both drugs share the same basic mechanism, combining them mainly extends coverage rather than adding a new mode of action.

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PDE5

Vardenafil

Vardenafil is a prescription medication of the phosphodiesterase type 5 (PDE5) inhibitor class, used to treat erectile dysfunction. Marketed under brand names such as Levitra and the orally disintegrating Staxyn, it improves the ability to achieve and maintain an erection by enhancing the body's natural response to sexual stimulation. It belongs to the same drug family as sildenafil and tadalafil and is taken on demand before sexual activity.

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Supplement

1-MNA

1-Methylnicotinamide (1-MNA) is an endogenous metabolite of nicotinamide produced by the enzyme nicotinamide N-methyltransferase (NNMT), and it sits within the nicotinamide and NAD+ salvage pathway. Long regarded as a biologically inert excretory product, it is now recognised as a vasoprotective, anti-thrombotic and anti-inflammatory agent that stimulates endothelial release of prostacyclin (PGI2) and nitric oxide [1][2]. It is marketed as a metabolic and longevity-oriented supplement.

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