nerve conduction

Every compound in the sci-wiki that affects nerve conduction; the ones you can source are floated to the front, then the reference-only entries. Tap any for the full entry, mechanism, and outlets.

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Nootropic

Ipidacrine

Ipidacrine is a genuine Cold War-era Soviet original, synthesized at the National Research Center for Biologically Active Compounds in Russia and pushed through the 1970s and 1980s under the code name NIK-247, decades before it ever appeared on a Western researcher's radar. Rather than working through the single acetylcholinesterase-inhibition mechanism most of its Western contemporaries relied on, it combines that AChE blockade with direct potassium-channel blockade at nerve and muscle membranes, a dual action that boosts both central cholinergic tone and peripheral nerve-impulse conduction. It remains sold and prescribed today in Russia and several post-Soviet states as Neuromidin (also called Amiridin or, in a topical form, Axamon), for memory disorders and peripheral nerve conditions, but it never went through Western-style FDA or EMA trials and stayed essentially invisible outside that regulatory sphere, a working drug that the rest of the world simply never met.

1 outlet

Anesthetic

Lidocaine

Lidocaine is a local anesthetic of the amide type and also a class Ib antiarrhythmic drug. It works by blocking the voltage-gated sodium channels that nerves use to fire, producing numbness where it is applied or injected. First made in the 1940s and sold under the brand name Xylocaine, it is one of the most widely used numbing agents in medicine and dentistry and appears on the World Health Organization's List of Essential Medicines.

2 outlets