Nausea

Every compound in the sci-wiki that affects nausea; the ones you can source are floated to the front, then the reference-only entries. Tap any for the full entry, mechanism, and outlets.

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Cannabinoid

Dronabinol

Dronabinol is a pharmaceutical cannabinoid that consists of synthetically produced (-)-trans-delta-9-tetrahydrocannabinol (delta-9-THC), the principal psychoactive constituent of Cannabis sativa, formulated as an oral agent. Marketed as Marinol (sesame-oil capsules) and Syndros (an oral solution), it is approved by the U.S. FDA for chemotherapy-induced nausea and vomiting refractory to conventional antiemetics and for anorexia associated with weight loss in patients with AIDS. It acts as a partial agonist at the CB1 and CB2 cannabinoid receptors of the endocannabinoid system, producing appetite stimulation, antiemetic effects, analgesia, and mood elevation. Dronabinol capsules were rescheduled from Schedule II to the less restrictive Schedule III in the United States, while the Syndros oral solution remains Schedule II.

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Adaptogen

Ginger

Ginger is the rhizome of Zingiber officinale, a flowering herbaceous perennial in the family Zingiberaceae that has served for millennia as both a culinary spice and a folk remedy. Native to Maritime Southeast Asia, where Austronesian peoples are thought to have first domesticated it, the plant is prized for its pungent, aromatic root, whose flavor derives chiefly from gingerols and related shogaols. Ginger is used fresh, dried, powdered, pickled, or candied, and among its many traditional uses it is most studied for easing nausea.

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Cannabinoid

Nabilone

Nabilone is a synthetic cannabinoid (a structural analog of delta-9-tetrahydrocannabinol) that acts as an agonist at the cannabinoid CB1 and CB2 receptors. Marketed as Cesamet, it is approved in the United States, Canada, the United Kingdom and other countries for the treatment of severe nausea and vomiting associated with cancer chemotherapy that has failed to respond to conventional antiemetics. Unlike inhaled cannabis or plant-derived THC, nabilone is a single, orally administered, pharmaceutically standardized molecule, which gives it consistent dosing and a defined pharmacokinetic profile. Beyond its licensed antiemetic indication, it has been studied off-label for neuropathic and chronic non-cancer pain, fibromyalgia, PTSD-associated nightmares, and agitation in Alzheimer's disease, with mixed but frequently encouraging results. Nabilone is a Schedule II controlled substance in the United States and a prescription-only medicine.

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