mood/psychosis

Every compound in the sci-wiki that affects mood/psychosis; the ones you can source are floated to the front, then the reference-only entries. Tap any for the full entry, mechanism, and outlets.

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Antipsychotic

Aripiprazole

Aripiprazole is a second-generation (atypical) antipsychotic used in schizophrenia, bipolar disorder and as an adjunct in major depression. Rather than fully blocking dopamine D2 receptors like older agents, it acts as a high-affinity partial agonist, combined with partial agonism at serotonin 5-HT1A and antagonism at 5-HT2A receptors, so that it behaves as a dopamine system stabilizer that dampens signaling where dopamine is excessive and supports it where dopamine is deficient. This mechanism gives it antipsychotic efficacy comparable to other agents with relatively little sedation, weight gain, movement disorder or prolactin elevation, and it is also formulated as a long-acting monthly injection to support adherence. The same partial-agonist pharmacology, however, can occasionally provoke impulse-control problems such as pathological gambling, an effect it shares with dopamine agonists.

2 outlets

Antipsychotic

Olanzapine

Olanzapine is an atypical, or second-generation, antipsychotic used to treat schizophrenia and bipolar disorder. Chemically a thienobenzodiazepine, it was discovered in a search for compounds resembling clozapine but without that drug's blood-monitoring requirement, and it works by blocking a broad range of dopamine and serotonin receptors. Beyond psychiatry it is a highly effective antiemetic and appetite stimulant even at very low doses, which is used in cancer care, though it is among the antipsychotics most likely to cause weight gain and metabolic problems, prompting the development of an olanzapine-samidorphan combination to blunt that effect.

2 outlets