Migraine

Every compound in the sci-wiki that affects migraine; the ones you can source are floated to the front, then the reference-only entries. Tap any for the full entry, mechanism, and outlets.

1 sourced · 1 reference

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Antimigraine

Sumatriptan

Sumatriptan is a medication of the triptan class, used to relieve acute migraine and cluster headache attacks. It works as a selective agonist of serotonin 5-HT1B and 5-HT1D receptors, narrowing dilated cranial blood vessels and dampening the nerve signaling that drives migraine pain. Introduced in the early 1990s as the first triptan, it is available as tablets, injections, and nasal sprays and appears on the World Health Organization's list of essential medicines.

2 outlets

reference shelf; no outlet carries these yet

Supplement

Vitamin B2 (Riboflavin)

Vitamin B2, or riboflavin, is a water-soluble essential vitamin and the precursor of two flavin coenzymes, flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD), that carry electrons through the redox reactions of energy metabolism. Because these flavoproteins sit at the center of the mitochondrial electron transport chain and of fatty-acid and amino-acid oxidation, riboflavin is fundamental to how cells turn food into ATP. Its best-supported use beyond simply correcting deficiency is high-dose prophylaxis of migraine, where topping up a rate-limiting mitochondrial cofactor is thought to shore up the brain's energy reserves. Chronic deficiency (ariboflavinosis) causes cracked lips, a sore inflamed tongue, and skin changes, while supplemental doses harmlessly turn the urine bright yellow-green.

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