Mast cell activity

Every compound in the sci-wiki that affects mast cell activity; the ones you can source are floated to the front, then the reference-only entries. Tap any for the full entry, mechanism, and outlets.

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Cannabinoid

Palmitoylethanolamide

Palmitoylethanolamide (PEA) is a naturally occurring fatty acid amide belonging to the N-acylethanolamine family. Produced in the body and also found in foods, it acts largely by activating the nuclear receptor PPAR-alpha and by dampening the activity of inflammatory cells such as mast cells. It has been studied mainly for chronic pain, inflammation, and neuroprotection, and it is sold as a dietary supplement or food for special medical purposes rather than as a conventional drug.

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Neuroprotection

Tetramethoxyluteolin

Tetramethoxyluteolin, also called methoxyluteolin, is a synthetic methylated derivative of the natural flavonoid luteolin, in which luteolin's four hydroxyl groups are replaced by methoxy groups, giving 3',4',5,7-tetramethoxyflavone. It is an investigational anti-inflammatory compound studied chiefly for its ability to inhibit human mast cells and other immune cells that drive allergic and inflammatory responses [2][3]. The methoxy substitution is intended to improve the molecule's stability and its ability to cross cell membranes compared with luteolin, and the compound has been examined mainly in laboratory research rather than in the clinic [1].

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