Lipids

Every compound in the sci-wiki that affects lipids; the ones you can source are floated to the front, then the reference-only entries. Tap any for the full entry, mechanism, and outlets.

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Supplement

Cinnamon

Cinnamon is a spice obtained from the dried inner bark of several evergreen trees in the genus Cinnamomum. It has been used since antiquity as a fragrant flavoring and in traditional medicine, and it owes its characteristic aroma largely to the compound cinnamaldehyde. Commercial cinnamon falls into two broad groups, the milder Ceylon or true cinnamon and the more common, stronger cassia, which differ markedly in their content of the compound coumarin.

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SERM

Raloxifene

Raloxifene is a benzothiophene selective estrogen receptor modulator (SERM) that binds both estrogen receptor subtypes with high affinity yet behaves as an agonist in some tissues and an antagonist in others. The molecular basis for this tissue selectivity is elegant: the bound ligand imposes a distinct conformation on the receptor that governs which coactivator or corepressor proteins are recruited at a given gene promoter, so the same drug preserves bone density and improves the lipid profile while blocking estrogen's proliferative signal in breast and endometrial tissue. Clinically it is used to prevent and treat postmenopausal osteoporosis and to lower the risk of invasive breast cancer in higher-risk women, a dual profile supported by the MORE, CORE, RUTH, and STAR trials. Because it does not stimulate the uterus, raloxifene carries a more favorable endometrial safety profile than tamoxifen, though it shares an increased risk of venous thromboembolism.

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