IGF-1

Every compound in the sci-wiki that affects igf-1; the ones you can source are floated to the front, then the reference-only entries. Tap any for the full entry, mechanism, and outlets.

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Peptide

GHRP-2

GHRP-2 (pralmorelin) is a synthetic growth hormone secretagogue, a ghrelin-mimetic that binds the ghrelin receptor (GHS-R1a) to trigger a pulse of the body's own growth hormone, and it also stimulates appetite and, to a lesser degree, ACTH and cortisol. Its growth-hormone response is reliable enough that it has been used clinically as a formal test of growth-hormone reserve, and it remains active by oral and intranasal routes. It is studied in the context of growth hormone deficiency, body composition, and recovery, and is used as a research peptide.

6 outlets

Growth Hormone

MK-777

MK-777, also styled Acetamoren, is marketed as an orally active growth hormone secretagogue in the same putative family as the well-characterized Ibutamoren (MK-677), and is presented as a ghrelin receptor agonist intended to amplify natural growth hormone and IGF-1 output. No published scientific record specific to MK-777 could be identified, so it is best regarded as an experimental compound whose rationale rests entirely on the biology of the growth hormone secretagogue class rather than on any direct evidence. For that class, non-peptide secretagogues acting at the growth hormone secretagogue receptor can restore youthful pulsatile growth hormone secretion and raise IGF-1, as demonstrated for MK-677. The citations here are provided as class-level context and do not characterize MK-777 itself; independent verification of its identity, potency, and safety is lacking.

1 outlet

Peptide

Sermorelin

Sermorelin is a synthetic analogue comprising the first 29 amino acids of growth hormone-releasing hormone (GHRH), the shortest fragment that retains full biological activity at the pituitary GHRH receptor. Rather than supplying growth hormone directly, it stimulates the somatotrophs to secrete the body's own hormone, preserving the natural pulsatile rhythm and leaving intact the negative feedback that guards against overexposure. Once approved for the diagnosis and treatment of growth hormone deficiency, it is now used chiefly in compounding and research settings, where interest centers on recovery, body composition, and sleep. The broader GHRH-receptor family it belongs to is under active study for effects well beyond the pituitary, including agonist protection in heart failure and antagonist activity against prostatic hyperplasia, fibrosis, and tumor growth.

5 outlets