Hippocampal neurogenesis

Every compound in the sci-wiki that affects hippocampal neurogenesis; the ones you can source are floated to the front, then the reference-only entries. Tap any for the full entry, mechanism, and outlets.

1 sourced · 1 reference

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Nootropic

Salicin

Salicin is an alcoholic beta-glucoside and a principal salicylate of willow (Salix) and poplar bark and meadowsweet, historically valued as a botanical analgesic and the conceptual forerunner of aspirin. Following ingestion it is hydrolyzed and oxidized to salicylic acid, the same active metabolite that mediates aspirin's effects, though at doses that spare much of the gastric irritation associated with acetylsalicylic acid. Mechanistic studies attribute its anti-inflammatory and antioxidant actions to suppression of the NF-kappaB and MAPK signaling pathways and activation of the Nrf2-heme oxygenase-1 axis, with additional contributions from co-occurring polyphenols and downstream catechol metabolites; salicin has also been identified as an agonist of the bitter taste receptor TAS2R16, a receptor-mediated route to resolving inflammation. Standardized willow bark preparations are used mainly for musculoskeletal and inflammatory pain, and their clinical activity is not fully accounted for by salicin content alone.

1 outlet

reference shelf; no outlet carries these yet

Nootropic

S 38093

Servier, the French pharmaceutical company, developed S 38093 as a histamine H3 receptor antagonist meant to work alongside existing Alzheimer's drugs rather than replace them, stimulating hippocampal neurogenesis and boosting acetylcholine release in a way that looked synergistic with donepezil in aged-mouse models. That preclinical promise carried it into two large international Phase II programs, one alone and one combined with donepezil, enrolling more than 1,300 patients with mild-to-moderate Alzheimer's disease across roughly 40 countries. After a year of dosing at three different levels, none of the arms beat placebo on cognition, function, clinical global impression, or caregiver burden, and treated patients had more falls than those on placebo; Servier discontinued the program on efficacy grounds despite the drug being otherwise reasonably well tolerated.

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