Heart Rhythm

Every compound in the sci-wiki that affects heart rhythm; the ones you can source are floated to the front, then the reference-only entries. Tap any for the full entry, mechanism, and outlets.

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Cardiovascular

Flecainide

Flecainide is a prescription Class Ic antiarrhythmic best known for suppressing ventricular and supraventricular arrhythmias, but it is featured here through an unconventional cognition and neuroprotection lens rather than its approved cardiac indication. The scientific hook is that flecainide, in addition to blocking the cardiac sodium channel, directly stabilizes the ryanodine receptor RyR2 and suppresses pathological intracellular calcium leak; the same RyR2 calcium leak has been implicated in neuronal dysfunction, tau pathology, and cognitive impairment in Alzheimer's models and in heart failure associated cognitive decline. A separate line of work shows that sodium channel blockade with flecainide protects axons from degeneration in neuroinflammatory models, which is a distinct neuroprotective rationale. Some users additionally pair a low dose antiarrhythmic with stimulants used for focus, reasoning that stimulants raise heart rate and arrhythmia risk while flecainide has proven antiarrhythmic action; this pairing is a theoretical, off label rationale rather than an established protocol. It is essential to be clear that human cognitive enhancement evidence for flecainide is preclinical or theoretical, and that flecainide remains a potent cardiac drug with a documented proarrhythmic risk in people with structural heart disease.

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Cardiovascular

Amiodarone

Amiodarone is a potent antiarrhythmic drug used to treat and prevent serious disturbances of the heart rhythm, particularly life-threatening ventricular arrhythmias and atrial fibrillation. Although classified as a class III agent, it acts on all phases of the cardiac electrical cycle and has properties spanning several antiarrhythmic classes. It is highly effective but notable for an unusually long duration of action and a wide range of potential side effects affecting the lungs, thyroid, liver, eyes, and skin [1].

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