Estrogen metabolism

Every compound in the sci-wiki that affects estrogen metabolism; the ones you can source are floated to the front, then the reference-only entries. Tap any for the full entry, mechanism, and outlets.

1 sourced · 1 reference

←estrogen metabolism2/2

Supplement

DIM

3,3'-Diindolylmethane (DIM) is the principal acid-condensation product of indole-3-carbinol, formed in the stomach from glucosinolates in cruciferous vegetables such as broccoli, cabbage, and kale. Its most studied action is as a selective aryl hydrocarbon receptor modulator: by engaging the AhR and interacting with estrogen receptor signaling, it influences cytochrome P450 enzymes that direct estrogen metabolism, favoring the 2-hydroxylation pathway over more proliferative metabolites. This dual AhR and estrogen-receptor activity underlies its investigation as a candidate in cancer chemoprevention, alongside reports of antiproliferative and even neuroprotective effects in cell models. The evidence remains largely preclinical and concentration-dependent, with some studies noting that low concentrations can paradoxically stimulate estrogen-receptor-positive cell growth, so its clinical role as a dietary supplement is still being defined.

1 outlet

reference shelf; no outlet carries these yet

Supplement

I3C

I3C (indole-3-carbinol) is a plant compound formed when cruciferous vegetables such as broccoli, cabbage and Brussels sprouts are chopped or chewed. It arises from the breakdown of the glucosinolate glucobrassicin and, in the acidic stomach, condenses into related molecules including DIM (3,3'-diindolylmethane). It is sold as a dietary supplement and is studied chiefly for its effects on estrogen metabolism and its potential to help prevent certain cancers.

reference