chemoreceptor trigger zone

Every compound in the sci-wiki that affects chemoreceptor trigger zone; the ones you can source are floated to the front, then the reference-only entries. Tap any for the full entry, mechanism, and outlets.

2 sourced · 0 reference

←chemoreceptor trigger zone2/2

Gastrointestinal

Metoclopramide

Metoclopramide is a medication that relieves nausea and vomiting and stimulates the movement of the upper digestive tract. Belonging to the benzamide class and acting mainly as a dopamine D2 receptor blocker, it is used for conditions such as chemotherapy-induced and post-surgical nausea, gastroparesis, and gastroesophageal reflux, and it is sold under brand names including Reglan and Maxolon. Because it can cause movement-related side effects with prolonged use, treatment courses are usually kept short, and it appears on the World Health Organization's list of essential medicines.

1 outlet

Gastrointestinal

Ondansetron

Ondansetron is a selective serotonin 5-HT3 receptor antagonist introduced in 1991 that blocks serotonin signaling in the gut and the brainstem vomiting center, making it a mainstay for chemotherapy, radiation, and postoperative nausea. Beyond antiemesis, its modulation of 5-HT3-gated neurotransmission has driven repurposing research; controlled trials found it reduced drinking in early-onset alcohol use disorder, with response predicted by serotonin transporter and 5-HT3 receptor genotype, positioning it as an early example of pharmacogenetically guided addiction treatment. It has also shown benefit in diarrhea-predominant irritable bowel syndrome by slowing colonic transit, and as an adjunct in schizophrenia it has been studied for effects on negative symptoms and cognition. Its principal safety consideration is dose-dependent QT-interval prolongation.

2 outlets