Cerebral vasculature

Every compound in the sci-wiki that affects cerebral vasculature; the ones you can source are floated to the front, then the reference-only entries. Tap any for the full entry, mechanism, and outlets.

1 sourced · 1 reference

←cerebral vasculature2/2

Nootropic

Nimodipine

Nimodipine is a dihydropyridine calcium channel blocker developed mainly to act on the blood vessels of the brain rather than as a general antihypertensive. Its principal approved role is preventing the delayed cerebral ischemia that can follow aneurysmal subarachnoid hemorrhage, a form of bleeding around the brain. It was patented in 1971 and reached clinical use in the 1980s, gaining United States approval in 1988. Because it relaxes cerebral arteries and shows relative selectivity for that circulation, it remains the only medication specifically approved to improve neurological outcomes after this type of stroke.

1 outlet

reference shelf; no outlet carries these yet

Nootropic

Adafenoxate

Adafenoxate is a little-known nootropic that is essentially the adamantane version of meclofenoxate (centrophenoxine). Like its parent it pairs an ester carrier with DMAE (dimethylaminoethanol), a choline-related molecule tied to acetylcholine and to membrane maintenance, but swaps the parent's chlorophenoxyacetic acid for a bulky adamantane group. Almost all of what is known comes from a cluster of Bulgarian rodent studies from the late 1980s and early 1990s, where it behaved like a cholinergic, monoamine-modulating, memory-protective agent. There is essentially no modern or human data, so it is a research curiosity rather than an established supplement.

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