Calcium: nootropics and compounds | sci-wiki

Drotaverine

Drotaverine (No-Spa) is a benzylisoquinoline antispasmodic, structurally related to papaverine, widely used outside the United States to relax smooth muscle in conditions such as renal and biliary colic, dysmenorrhea and gastrointestinal cramp. Its relaxant action combines PDE4 inhibition (raising cAMP) with L-type calcium-channel blockade. A single 2021 mouse study reported that it reversed streptozotocin-induced Alzheimer-type deficits, but there is no human cognition data.

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Analgesic

4-Methylpregabalin

4-Methylpregabalin is an investigational gabapentinoid (an alpha2delta calcium-channel ligand) and a close structural analog of pregabalin, carrying an additional methyl group at the 4-position of the aminomethyl-hexanoic-acid backbone (IUPAC 3-(aminomethyl)-4,5-dimethylhexanoic acid). Synthesized by Parke-Davis/Pfizer during structure-activity studies on the gabapentin and pregabalin scaffold, its active (3S,4S) stereoisomer binds the alpha2delta-1 auxiliary subunit of voltage-gated calcium channels with high affinity and produces anticonvulsant, analgesic and anxiolytic activity in preclinical models, in several of which it is reported to be more potent than pregabalin. It was never advanced to clinical trials or market and remains a research compound.

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Supplement

Calcium L-Threonate

Calcium L-threonate is the calcium salt of L-threonic acid, a metabolite of vitamin C, marketed as a highly absorbable mineral supplement for bone and connective-tissue health [1]. In a human pharmacokinetic study, orally administered L-threonate was absorbed rapidly, was well tolerated across single and repeated doses, and showed enhanced absorption when taken with food [1]. It should not be confused with magnesium L-threonate; calcium L-threonate delivers elemental calcium and its threonate carrier for bone and collagen support, without the blood-brain-barrier and cognitive claims attached to the magnesium form [1].

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Supplement

Menaquinone-7

Menaquinone-7 (MK-7) is a long-chain form of vitamin K2, one of the naturally occurring menaquinones distinguished by a side chain of seven isoprenoid units. It is produced by bacterial fermentation and is found most abundantly in the Japanese fermented soybean dish natto. Like other K vitamins, it acts as a cofactor for the enzyme that activates vitamin K-dependent proteins involved in blood clotting, bone mineralization, and the regulation of soft-tissue calcification. Compared with shorter menaquinones and with vitamin K1, MK-7 has a notably long half-life in the bloodstream, which has helped make it a popular dietary supplement.

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