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Every compound in the sci-wiki that affects buffering; the ones you can source are floated to the front, then the reference-only entries. Tap any for the full entry, mechanism, and outlets.
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Beta-alanine is a naturally occurring amino acid and the main building block the body uses to make carnosine, a compound stored in muscle that helps buffer the acid produced during hard exercise. Taken as a supplement over several weeks, it raises muscle carnosine levels and can modestly improve performance in high-intensity efforts lasting roughly one to several minutes. Its most familiar effect is a harmless skin tingling called paresthesia.
Carnosine is a naturally occurring dipeptide made of the amino acids beta-alanine and L-histidine, found in high concentrations in skeletal muscle and the brain. It acts inside cells chiefly as a pH buffer during intense exercise and as an antioxidant that also protects proteins from glycation. Because dietary beta-alanine is the limiting ingredient for making it, beta-alanine supplements are commonly used to raise muscle carnosine, and carnosine itself is sold as a supplement studied for exercise, aging, and neurological health.