Brain / cognition

Every compound in the sci-wiki that affects brain / cognition; the ones you can source are floated to the front, then the reference-only entries. Tap any for the full entry, mechanism, and outlets.

1 sourced · 1 reference

←brain / cognition2/2

Nootropic

ACP-105

ACP-105 is a potent nonsteroidal selective androgen receptor modulator (SARM) engineered to deliver the muscle- and bone-building benefits of androgens with greater tissue selectivity than testosterone. As a partial agonist at the androgen receptor, it was designed to drive anabolism in muscle and bone while limiting the unwanted effects tied to classic steroids. Its combination of anabolic potency and an intriguing signal for cognitive and neuroprotective effects has made it a standout among research-grade SARMs.

1 outlet

reference shelf; no outlet carries these yet

Nootropic

DHED

DHED (10-beta,17-beta-dihydroxyestra-1,4-dien-3-one) is an experimental bioprecursor prodrug of the estrogen 17-beta-estradiol that is inert at estrogen receptors until it is converted to the active hormone. Its defining feature is a striking tissue selectivity: a reductase reaction that occurs in nervous tissue regenerates estradiol within the brain and retina after systemic or topical dosing, while the molecule remains unchanged in the periphery, so it does not raise circulating estrogen or stimulate the uterus, breast, or pituitary. In rodent models this brain-restricted delivery has relieved menopausal and androgen-deprivation hot flushes, provided neuroprotection after stroke, and, as eye drops, preserved retinal ganglion cells and visual function in glaucoma models. DHED remains a preclinical agent, but it exemplifies a prodrug strategy aimed at capturing estrogen's central benefits while avoiding the systemic risks that limit conventional hormone therapy.

reference