alpha-1 adrenergic receptors

Every compound in the sci-wiki that affects alpha-1 adrenergic receptors; the ones you can source are floated to the front, then the reference-only entries. Tap any for the full entry, mechanism, and outlets.

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Cardiovascular

Midodrine

Midodrine is an orally administered alpha-1 adrenergic receptor agonist used mainly to treat symptomatic orthostatic hypotension, the fall in blood pressure that occurs on standing. It acts as a prodrug, converting in the body to the active compound desglymidodrine, which narrows blood vessels and raises blood pressure. Marketed under brand names such as ProAmatine and Gutron, it was approved for medical use in the United States in 1996 and is now available as a generic.

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Cardiovascular

Prazosin

Prazosin is a selective alpha-1 adrenergic receptor antagonist (an alpha-1 blocker) of the quinazoline class. Introduced in the 1970s to treat high blood pressure, it relaxes blood vessels and smooth muscle, and it is now also used off-label to reduce the nightmares and sleep disruption of post-traumatic stress disorder, to ease the urinary symptoms of an enlarged prostate, and in Raynaud's phenomenon. It is sold under the brand name Minipress and is widely available as a generic oral medicine.

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Cardiovascular

Tamsulosin

Tamsulosin is a medication of the alpha-1 adrenergic receptor antagonist class, commonly called an alpha blocker, sold under brand names such as Flomax. It is used mainly to ease the urinary symptoms of an enlarged prostate and to help small stones pass through the ureter. It works by relaxing smooth muscle in the prostate, bladder neck, and urinary tract rather than by shrinking the prostate.

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