Ephylone

Ephylone, also known as N-ethylpentylone or N-ethylnorpentylone, is a methylenedioxy-substituted synthetic cathinone that behaves primarily as a psychostimulant rather than an entactogen. In vitro assays show it is a potent blocker of the dopamine and norepinephrine transporters, with weaker activity at the serotonin transporter and no measurable transporter-releasing action, so it raises extracellular catecholamines chiefly by reuptake inhibition. Animal studies report locomotor sensitization, hyperthermia, conditioned place preference, and persistent striatal FosB accumulation, findings consistent with a high abuse and dependence liability and a comparatively long duration with harsh comedowns. It has been implicated in numerous intoxications and fatalities, frequently after being sold as MDMA or cocaine, with clinical features spanning agitation, tachycardia, hallucinations, and cardiovascular collapse.