class, effects, and the receptor fingerprint, side by side; add up to four, then source the whole stack
Popular head-to-heads →Alpha4beta2 nicotinic (a4b2 nAChR)high-affinity partial agonist
Alpha7 nicotinic (a7)full agonist
Alpha3beta4 nicotinic (a3b4)partial agonist
Alpha6beta2* nicotinic (a6-containing)weak partial agonist
Alpha3beta2 nicotinic (a3b2)weak partial agonist
Alpha4beta2 nicotinic (a4b2 nAChR)high-affinity partial agonist (low intrinsic efficacy)
Alpha3beta4 nicotinic (a3b4)full/high-efficacy agonist
Alpha7 nicotinic (a7)partial-to-full agonist
Alpha6beta2* nicotinic (a6-containing)weak/low-efficacy partial agonist
Nicotine-evoked striatal dopamine releasepartially substitutes / attenuates
checking Varenicline and Cytisine: no notable interaction flagged; they read as broadly independent.
no notable interaction flagged; these look broadly independent.
General educational info, not medical advice.