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for educational and safety purposes
class, effects, and the receptor fingerprint, side by side; add up to four, then source the whole stack
Popular head-to-heads →Mu-opioid receptor (MOR)partial agonist
Kappa-opioid receptor (KOR)antagonist
Delta-opioid receptor (DOR)antagonist
Nociceptin/ORL1 (NOP) receptorpartial agonist
Mu-opioid receptor (slow dissociation)blocks
Opioid receptors (mu)antagonist
Microglia / TLR4 (low dose)inhibits
Endorphin signalingupregulates (rebound)
checking Buprenorphine and Naltrexone: at least one combination is flagged to avoid (1 to avoid). treat the red pairs as a reason to reconsider mixing.
two strong CNS depressants (opioid, benzodiazepine, z-drug, barbiturate, gabapentinoid, GABAergic or alcohol) add together on sedation and breathing; a leading cause of fatal respiratory depression.
General educational info, not medical advice.