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for educational and safety purposes
class, effects, and the receptor fingerprint, side by side; add up to four, then source the whole stack
Popular head-to-heads →Modafinil (active metabolite)converts to
Dopamine transporterweakly inhibits
Orexin / histamine (wake systems)activates
Liverprocessed by
Dopamine transporter (DAT)weak selective inhibitor
Norepinephrine transporterinhibits
Orexin / histamineraises
Dopamine transporter (DAT, SLC6A3)Inhibitor; blocks dopamine reuptake. The primary and only well-established direct molecular target.
Norepinephrine transporter (NET, SLC6A2)Negligible direct binding at attainable concentrations.
Serotonin transporter (SERT, SLC6A4)No meaningful interaction demonstrated.
Dopamine D2/D3 receptorsIndirect. Apparent occupancy changes because synaptic dopamine rises, not because modafinil binds the receptor.
Dopamine D1 receptorDownstream mediator of behavioural effect, not a binding site.
Orexin/hypocretin neurons (perifornical hypothalamus)Indirect circuit activation; not required for wake promotion.
Histaminergic tuberomammillary nucleus (TMN) neuronsIndirect circuit activation.
Mesencephalic dopamine neurons (VTA and substantia nigra pars compacta)Required downstream circuit for arousal.
checking Adrafinil and Modafinil: no hard conflicts (1 to watch), but the amber pairs carry interactions to be careful with.
two stimulants add cardiovascular and jitter load when combined; a pairing to be careful with.
General educational info, not medical advice.
The vendors that carry the most of your 2 picks; fewer vendors, fewer codes, less shipping.
Carries Adrafinil
codeSeanCarries Modafinil
codeScientificCarries Modafinil
No single vendor carries the whole stack — the top pick covers 1 of 2 sourceable picks; grab the rest from the next vendor.