Loading…
for educational and safety purposes
BPN14770 and HT-0712 both come up in the same conversations. BPN14770: BPN14770, also known as zatolmilast, is an investigational drug that inhibits the phosphodiesterase-4D (PDE4D) enzyme through an allosteric mechanism, binding a regulatory domain rather than the catalytic site so that inhibition is only partial. HT-0712: HT-0712 (betamilast) is a PDE4 inhibitor purpose-engineered to be a memory drug.
BPN14770, also known as zatolmilast, is an investigational drug that inhibits the phosphodiesterase-4D (PDE4D) enzyme through an allosteric mechanism, binding a regulatory domain rather than the catalytic site so that inhibition is only partial. This partial, subtype-selective action raises the signaling molecule cyclic AMP in the brain to enhance memory while avoiding the nausea and emesis that limited earlier pan-PDE4 inhibitors. It has been studied for Fragile X syndrome, where it improved cognition in a phase 2 trial, and for Alzheimer's disease; it reached phase 2 trials but is not approved for medical use.
HT-0712 (betamilast) is a PDE4 inhibitor purpose-engineered to be a memory drug. Designed across Inflazyme, Helicon and Dart NeuroScience, it targets the CREB memory pathway with a wider therapeutic window than the notoriously emetic rolipram. In animals it selectively boosts long-term (not short-term) memory in normal and aged mice, and it reached Phase 2 testing in age-associated memory impairment, making it the most deliberately memory-focused candidate in the PDE4 class.
both fingerprints on one instrument; where the marks line up the two compounds work the same lever, where a slot goes dark only one of them touches it. read straight from each entry's affinity table; nothing here is invented.
allosteric inhibitor
activates
Activates (downstream)
Inhibits
Increases (downstream)
Activates (downstream)
strengths are the entries' qualitative ratings (strong / moderate / weak); Ki and EC50 figures appear where an entry records them.
easiest to source: BPN14770 is currently listed by more trusted vendors (1), so it's the simpler one to get hold of. for effects and safety, read each full entry; this is educational, not medical advice.