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for educational and safety purposes
Anandamide and 2-Arachidonoylglycerol both come up in the same conversations. Anandamide: Anandamide, also known as N-arachidonoylethanolamine, is a naturally occurring fatty-acid neurotransmitter and the first endocannabinoid to be identified. 2-Arachidonoylglycerol: 2-Arachidonoylglycerol (2-AG) is an endogenous cannabinoid (endocannabinoid) that serves as the principal full agonist of the CB1 and CB2 cannabinoid receptors in the mammalian body.
Anandamide, also known as N-arachidonoylethanolamine, is a naturally occurring fatty-acid neurotransmitter and the first endocannabinoid to be identified. Discovered in 1992, it is produced on demand in the body from membrane lipids and binds the same cannabinoid receptors targeted by compounds in cannabis. It takes part in the regulation of mood, appetite, memory, pain, and fertility, and is broken down rapidly by the enzyme fatty acid amide hydrolase.
2-Arachidonoylglycerol (2-AG) is an endogenous cannabinoid (endocannabinoid) that serves as the principal full agonist of the CB1 and CB2 cannabinoid receptors in the mammalian body. A monoacylglycerol built from arachidonic acid esterified to glycerol, it was isolated from rat brain and canine gut in 1995 and is now regarded as the most abundant endocannabinoid in the central nervous system. Unlike a stored transmitter, 2-AG is synthesized on demand from membrane phospholipids by sn-1-diacylglycerol lipases (DAGL-alpha and DAGL-beta) in response to elevated intracellular calcium, then released to act as a retrograde messenger at synapses before being rapidly hydrolyzed back to arachidonic acid and glycerol by monoacylglycerol lipase (MAGL). Through this signaling it modulates synaptic plasticity, pain, appetite, mood, neuroinflammation, and immune and cardiovascular function, and it is a central node of the wider endocannabinoid system.
both fingerprints on one instrument; where the marks line up the two compounds work the same lever, where a slot goes dark only one of them touches it. read straight from each entry's affinity table; nothing here is invented.
partial agonist
Full agonist
partial agonist
Full agonist
substrate
activates
modulates
Biosynthetic product
Substrate (hydrolyzed)
Oxidative substrate
Indirect activation
Weak agonist/modulator
strengths are the entries' qualitative ratings (strong / moderate / weak); Ki and EC50 figures appear where an entry records them.