Stress resistance

Every compound in the sci-wiki that affects stress resistance; the ones you can source are floated to the front, then the reference-only entries. Tap any for the full entry, mechanism, and outlets.

2 sourced · 0 reference

←stress resistance2/2

Nootropic

Chlodantane

Chlodantane is a chlorinated adamantane derivative, N-(2-adamantyl)-4-chlorobenzamide, developed in Russia as part of the adamantane actoprotector program at the Zakusov Institute, the same program that produced bromantane. The sole indexed publication describing it directly is a 1999 Russian review of 329 synthesized adamantane derivatives, which identifies 2-(para-chlorobenzoylamine)adamantane as a rapid-action compound enhancing resistance to emergencies such as hyperthermia and hypoxia, alongside bromantane's more endurance-oriented profile [1]. No dedicated pharmacology, toxicology or clinical papers on chlodantane are indexed in PubMed. Its expected pharmacology is inferred from the adamantane actoprotector class, including dopaminergic modulation and stress resistance without increased oxygen consumption [2] [3].

1 outlet

Peptide

Humanin

Humanin is a 24-amino-acid mitochondrial-derived peptide and one of the first signaling molecules found to be encoded within the mitochondrial genome rather than the nucleus, translated from a short open reading frame inside the 16S ribosomal RNA region. It was first identified in the surviving neurons of an Alzheimer's-affected brain as a rescue factor, and it is broadly cytoprotective; a well-characterized part of its anti-apoptotic action is that it directly binds the pro-death protein BAX and sequesters it away from the mitochondrial membrane. It has been reported to improve insulin sensitivity, protect the heart against ischemic injury, and correlate with longevity, with higher circulating levels in the offspring of centenarians, and it is studied as a target in aging and neurodegeneration.

3 outlets