stress reactivity

Every compound in the sci-wiki that affects stress reactivity; the ones you can source are floated to the front, then the reference-only entries. Tap any for the full entry, mechanism, and outlets.

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←stress reactivity2/2

Serotonergic

Deramciclane

Deramciclane came out of EGIS Pharmaceuticals in Hungary as a non-benzodiazepine anxiolytic working through 5-HT2A/2C receptors instead of GABA-A, and Orion Pharma partnered on it to run one of the largest clinical programs in Orion's 20-year research history. Early dose-finding data in generalized anxiety disorder actually looked encouraging; the 60 mg/day arm cleared the psychic-anxiety subscale of the HAM-A against placebo. That promise collapsed when the larger Phase III studies read out; Orion announced in 2003 that deramciclane simply lacked sufficient efficacy in GAD, closing out a program that had consumed years of investment on a hopeful mechanistic bet.

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Neuropeptide

Nelivaptan

Nelivaptan chased a genuinely novel idea in psychiatry, blocking the vasopressin V1b receptor instead of tuning serotonin or GABA, on the logic that vasopressin drives the body's stress and HPA-axis response and that dialing it down might relieve anxiety and depression without the sedation or dependence baggage of benzodiazepines. Sanofi-Aventis ran it through four large, well-controlled Phase II trials for major depressive disorder and generalized anxiety disorder between 2006 and 2008, comparing it against escitalopram and paroxetine. The results were unambiguous in the wrong direction; nelivaptan showed no meaningful benefit over placebo in GAD and only inconsistent signals in depression, closing the book on vasopressin antagonism as an anxiety treatment for over a decade.

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