Stress

Every compound in the sci-wiki that affects stress; the ones you can source are floated to the front, then the reference-only entries. Tap any for the full entry, mechanism, and outlets.

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Opioid

Norbinaltorphimine

Norbinaltorphimine, commonly abbreviated nor-BNI, is a selective antagonist of the kappa-opioid receptor used almost exclusively as a research tool. Chemically it is a bivalent, or dimeric, derivative of the morphinan scaffold, built from two linked opioid-like units. It is valued in pharmacology for its strong selectivity for the kappa-opioid receptor over the mu and delta subtypes and for an unusually long duration of action that can persist for weeks after a single dose. It is a research chemical rather than an approved medicine, and in the United States it is a controlled substance.

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Neurosteroid

THDOC

THDOC (3-alpha,5-alpha-tetrahydrodeoxycorticosterone) is an endogenous neurosteroid (a steroid that acts rapidly on neuronal membrane receptors rather than on classical nuclear hormone receptors) and the fully reduced 3-alpha,5-alpha metabolite of the adrenal steroid deoxycorticosterone. It is one of the most potent naturally occurring positive allosteric modulators (compounds that amplify a receptor's response to its own transmitter) of the GABA-A receptor, the brain's principal inhibitory chloride ion channel, where it enhances both fast synaptic and sustained extrasynaptic inhibition. Because its synthesis is driven by adrenocorticotropic hormone and by acute stress, THDOC is regarded as a stress-responsive inhibitory neurosteroid that provides negative feedback on the hypothalamic-pituitary-adrenal axis and transiently raises the seizure threshold. Alongside allopregnanolone, it is a prototypical member of the stress-derived GABAergic neurosteroid family.

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