Steroidogenesis

Every compound in the sci-wiki that affects steroidogenesis; the ones you can source are floated to the front, then the reference-only entries. Tap any for the full entry, mechanism, and outlets.

1 sourced · 1 reference

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Peptide

N163-166 (MOD6)

N163-166 (MOD6) is an orally active peptide engineered to switch the body's own testosterone production back on at its source. It targets VDAC1, a mitochondrial gatekeeper that governs the rate-limiting step of steroid synthesis, prompting the Leydig cells of the testes to make more testosterone rather than supplying an outside hormone. In male rats, VDAC1-derived oral peptides raised circulating testosterone specifically through the natural gonadal axis, and stabilizing modifications let this small peptide survive oral dosing [1]. It is an investigational research compound.

1 outlet

reference shelf; no outlet carries these yet

Hormone

6-Ketoprogesterone

6-Ketoprogesterone (systematic name pregn-4-ene-3,6,20-trione) is a synthetic oxidised derivative and minor oxidative metabolite of progesterone in which an additional ketone (a carbonyl group) is introduced at the sixth carbon of the steroid B-ring. First isolated from perfused human placentae in 1956 and characterised pharmacologically in Japan in 1958, it is notable for having lost the classical progestational activity of its parent hormone while retaining a weaker, progesterone-like depressant action on the central nervous system. Today it exists chiefly as a pharmacopeial reference standard (a purified compound used to calibrate analytical assays), as a mechanistic probe for the C6 oxidation of progesterone, and as a metabolic curiosity of pregnancy endocrinology. Its status as a genuinely endogenous neurosteroid remains uncertain, so it is treated conservatively as non-endogenous.

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