sodium retention

Every compound in the sci-wiki that affects sodium retention; the ones you can source are floated to the front, then the reference-only entries. Tap any for the full entry, mechanism, and outlets.

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Corticosteroid

Fludrocortisone

Fludrocortisone is a synthetic corticosteroid with strong mineralocorticoid activity, meaning it acts much like the natural hormone aldosterone to make the kidneys hold on to sodium and water. It is used mainly to replace missing hormones in adrenal insufficiency, including Addison's disease and the salt-losing form of congenital adrenal hyperplasia, and to raise blood pressure in some people with orthostatic hypotension. Marketed as the acetate ester under the brand name Florinef, it is taken by mouth and appears on the World Health Organization's List of Essential Medicines. It also holds a place in pharmaceutical history as one of the first synthetic corticosteroids and the first fluorinated drug to reach the market.

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Neurosteroid

Deoxycorticosterone

Deoxycorticosterone (11-deoxycorticosterone, 21-hydroxyprogesterone; also called cortexone or desoxycortone) is an endogenous steroid hormone made by the adrenal cortex that functions both as a mineralocorticoid and as the metabolic precursor to a potent neurosteroid. Acting through the mineralocorticoid receptor (a ligand-activated transcription factor that governs sodium and water balance), it promotes renal salt retention with an affinity close to that of aldosterone. Its principal relevance to neuropharmacology is as the parent compound of 3-alpha,5-alpha-tetrahydrodeoxycorticosterone (THDOC), a positive allosteric modulator of the GABA-A receptor (the brain's main inhibitory chloride channel) that is released during stress and shapes seizure threshold, anxiety, and hypothalamic-pituitary-adrenal (HPA) axis activity. Deoxycorticosterone should not be confused with the psychedelic amphetamine also abbreviated DOC (2,5-dimethoxy-4-chloroamphetamine), which is an entirely unrelated compound.

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