Skin firmness

Every compound in the sci-wiki that affects skin firmness; the ones you can source are floated to the front, then the reference-only entries. Tap any for the full entry, mechanism, and outlets.

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Peptide

Argireline

Argireline is a trade name for acetyl hexapeptide-3 (also called acetyl hexapeptide-8), a synthetic six-amino-acid peptide used as an anti-wrinkle ingredient in cosmetics. Introduced in the early 2000s, it is marketed as a topical, needle-free alternative to botulinum toxin, on the idea that it can relax the small facial muscle contractions that form expression lines. Its peptide sequence mimics part of a natural protein involved in nerve-to-muscle signaling, and the evidence for its effect, while suggestive, is limited.

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Peptide

Pal-GHK (Palmitoyl Tripeptide-1)

Pal-GHK, also known as palmitoyl tripeptide-1, is a synthetic cosmetic peptide made by attaching a palmitic acid chain to the human tripeptide GHK (glycyl-L-histidyl-L-lysine). The fatty acid tail makes the peptide more lipophilic so it can better penetrate the skin, where GHK-based signals are known to stimulate collagen and support extracellular matrix repair. It is used as a signaling ingredient in anti-aging skincare rather than as a medicine.

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Supplement

Phloretin

Phloretin is a dihydrochalcone, a naturally occurring plant phenol found in apples, apple tree leaves, and the Manchurian apricot. It is the aglycone of phlorizin, meaning the sugar-free core of that better-known apple compound, and it is studied chiefly as an antioxidant and as an inhibitor of glucose transport across cell membranes. Phloretin appears as an ingredient in some skincare products and is a subject of laboratory research, but it is not an approved medicine.

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