skeletal muscle tone

Every compound in the sci-wiki that affects skeletal muscle tone; the ones you can source are floated to the front, then the reference-only entries. Tap any for the full entry, mechanism, and outlets.

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Muscle Relaxant

Cyclobenzaprine

Cyclobenzaprine is a centrally acting skeletal muscle relaxant used for the short-term relief of muscle spasm and pain from acute musculoskeletal conditions. Structurally it is a tricyclic compound closely related to the antidepressant amitriptyline, differing by only a single double bond in its ring system, and it does not act directly on muscle but rather within the central nervous system. First approved in the United States in 1977 and long sold under the brand name Flexeril, it is a common prescription medication and has also been studied for fibromyalgia.

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Muscle Relaxant

Tizanidine

Tizanidine is a centrally acting muscle relaxant of the alpha-2 adrenergic agonist class, used to reduce the spasticity caused by conditions such as multiple sclerosis, stroke, and spinal cord injury [1]. Structurally related to clonidine, it works within the central nervous system to calm overactive muscle reflexes rather than acting on muscle directly. It was approved in the United States in 1996 and is sold under brand names including Zanaflex and Sirdalud.

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