Short-Term Memory

Every compound in the sci-wiki that affects short-term memory; the ones you can source are floated to the front, then the reference-only entries. Tap any for the full entry, mechanism, and outlets.

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Nootropic

Farampator

Farampator (CX-691 / Org 24448) is an investigational ampakine, a positive allosteric modulator of AMPA-type glutamate receptors, advanced through the Cortex Pharmaceuticals / Organon program. It slows AMPA-receptor deactivation and desensitization to strengthen fast excitatory transmission and long-term potentiation, and in animals it raises hippocampal and prefrontal acetylcholine, prefrontal dopamine, and hippocampal BDNF mRNA. It is best known for a single, unusually instructive human trial in which one 500 mg dose improved short-term memory yet impaired episodic memory in healthy elderly volunteers.

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Nootropic

Rolziracetam

Rolziracetam was developed as CI-911 during the 1980s racetam research wave that piracetam's success touched off across European and American pharma chemistry, one of many cyclic-imide/pyrrolidinone analogs screened for "amnesia-reversal" activity against scopolamine-induced memory deficits in rodents, the field's standard nootropic assay at the time. It performed in that classic screening model and had its metabolic disposition characterized in animal studies, but like most second-generation racetams it never accumulated the human efficacy data needed to reach market. The entire racetam class shared the same problem: a diffuse, hard-to-pin-down mechanism that made regulatory approval an uphill argument, and once the pharmaceutical industry's attention moved to more mechanistically defined drug classes, compounds like rolziracetam simply stopped being worth developing further.

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