Psychosis

Every compound in the sci-wiki that affects psychosis; the ones you can source are floated to the front, then the reference-only entries. Tap any for the full entry, mechanism, and outlets.

0 sourced · 4 reference

←psychosis4/4

Nootropic

Emraclidine

A selective M4 positive allosteric modulator built at Pfizer and carried into schizophrenia trials by Cerevel and then AbbVie, whose phase 2 programme failed to beat placebo in November 2024.

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Nootropic

LY2033298 is a preclinical positive allosteric modulator of the M4 muscarinic acetylcholine receptor; it was the first small molecule selective enough to test whether activating M4 on its own could produce an antipsychotic effect.

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Nootropic

VU0467154

VU0467154 is a preclinical positive allosteric modulator of the M4 muscarinic receptor, built at Vanderbilt as an in vivo tool compound, and it is the molecule most of the rodent evidence for the M4 antipsychotic hypothesis actually rests on.

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Nootropic

Xanomeline

An M1/M4-preferring muscarinic agonist that failed as an Alzheimer's drug in the 1990s and returned in 2024 as the active antipsychotic half of Cobenfy, the first schizophrenia treatment approved without dopamine receptor blockade.

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