Pruritus

Every compound in the sci-wiki that affects pruritus; the ones you can source are floated to the front, then the reference-only entries. Tap any for the full entry, mechanism, and outlets.

0 sourced · 2 reference

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Dermatological

Crisaborole

Crisaborole (Eucrisa) is a boron-containing, non-steroidal topical PDE4 inhibitor, FDA-approved in December 2016 for mild-to-moderate atopic dermatitis (eczema) in patients aged three months and older. Two pivotal Phase 3 trials showed superior skin clearance and itch relief versus vehicle with a favorable safety profile. Honesty note: this is a skin drug with negligible systemic absorption and no CNS or cognition relevance whatsoever; it is included here only for PDE4-class completeness, not as a nootropic.

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Dermatological

Difamilast

Difamilast (Moizerto) is a selective, PDE4B-preferring topical PDE4 inhibitor and the first PDE4 inhibitor approved in Japan (2021) for atopic dermatitis in patients aged two years and older. Two Phase 3 trials in adults and children showed clear eczema clearance superior to vehicle with a rapid antipruritic effect. Like crisaborole, it is a skin drug with negligible systemic exposure and no CNS or cognition evidence; included here for PDE4-class completeness, not as a nootropic.

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