peripheral circulation

Every compound in the sci-wiki that affects peripheral circulation; the ones you can source are floated to the front, then the reference-only entries. Tap any for the full entry, mechanism, and outlets.

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Anticoagulant

Cilostazol

Cilostazol is a phosphodiesterase 3 inhibitor with combined antiplatelet and vasodilator effects, used mainly to relieve the leg pain of intermittent claudication in peripheral artery disease. By raising levels of the signaling molecule cyclic AMP, it widens blood vessels and discourages platelets from clumping, which can lengthen the distance a person is able to walk before pain sets in. It was approved in the United States in 1999 and carries a warning against use in people with heart failure.

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Cardiovascular

Pentoxifylline

Pentoxifylline is a methylxanthine derivative used as a hemorheologic agent, meaning a drug that improves the flow properties of blood. Marketed under the brand name Trental, it is approved chiefly to relieve intermittent claudication, the leg pain on walking that results from peripheral artery disease. It acts by making red blood cells more flexible and by lowering blood viscosity, and it also has anti-inflammatory effects that have prompted study in a range of other conditions.

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