for educational and safety purposes
Every compound in the sci-wiki that affects nitric oxide/cgmp; the ones you can source are floated to the front, then the reference-only entries. Tap any for the full entry, mechanism, and outlets.
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Avanafil is a phosphodiesterase type 5 (PDE5) inhibitor used to treat erectile dysfunction, sold under the brand names Stendra and Spedra. It is notable for its fast onset, being absorbed within roughly thirty to forty-five minutes, and for its high selectivity for the PDE5 enzyme. Invented at Mitsubishi Tanabe Pharma and approved by the US Food and Drug Administration in 2012, it works by boosting the nitric-oxide signaling that relaxes blood vessels in the penis.
Vardenafil plus dapoxetine is a combination of two drugs used together to treat men who have both erectile dysfunction and premature ejaculation. Vardenafil is a phosphodiesterase type 5 (PDE5) inhibitor that improves erections, while dapoxetine is a short-acting selective serotonin reuptake inhibitor (SSRI) that delays ejaculation. The pairing is taken on demand before sexual activity and is marketed as a fixed-dose combination in some countries.